Antidysrhythmic agents, which are also known as antiarrhythmic agents, are a broad category of medications that help ameliorate the spectrum of cardiac. The ultimate goal of antiarrhythmic drug therapy is to restore normal rhythm and conduction. When it is not possible to revert to normal sinus rhythm, drugs may. Antidysrhythmic Drugs: Amiodarone, Digoxin, Disopyramide, Flecainide, Lidocaine, Procainamide, Quinidine answers are found in the Davis’s Lab & Diagnostic.

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Freeman, and Jeffrey S.

With regard to management of atrial fibrillation, classes I and III are used in rhythm control as medical cardioversion agents, while classes II and IV are used as rate-control agents. Antiarrhythmic drugs are used to:. A new approach to the classification of antiarrhythmic drugs based on their actions on arrhythmogenic mechanisms.

Pharmacology and the nursing process 5th ed. Class IV drugs are calcium channel blockers which inhibit the calcium antidysthythmic reducing the movement of calcium ions in the cells during action potentials. They also have potassium channel blocking properties, and so increase action potential duration and the effective refractory period. Decrease myocardial infarction mortality Prevent recurrence of tachyarrhythmias Propranolol has sodium channel-blocking effects.

The ‘stabilizing’ word is used to describe the decrease of excitogenicity of the plasma membrane which is brought about by these agents.

Antiarrhythmic agent – Wikipedia

Email required Address never made public. In other projects Wikimedia Commons. To antiidysrhythmic out more, including how to control cookies, see here: Clinical Sports Medicine Collection. Medical Pharmacology and Therapeutics E-Book. Class I agents are called membrane-stabilizing agents.


These channels determine how fast the membrane depolarizes phase 0 during an action potential.

Antiarrhythmic Drugs

Many attempts have been made to classify antiarrhythmic agents. The initial classification system had 4 classes, although their definitions different from the modern classification.

Class II agents are conventional beta blockers. Views Read Edit View history. There are four classes of antidysrhytmics which each have a different mechanism of action. Arrhythmias generally arise as a result of abnormal impulse generation or abnormal conduction, or a combination of the two. In the case of AV block, drugs that block vagal influences e. Journal of the American College of Nutrition.

When it is not possible to revert to normal sinus rhythm, drugs may be used to prevent more serious and possibly lethal arrhythmias from occurring. A recent publication has now emerged with a fully modernised drug classification. This site uses cookies to provide, maintain and improve your experience.

With either form, it requires a preceding triggering beat to create the abnormal depolarization. It presents the drugs on two axes, instead druts one, and is presented in tabular form. Sign in via Shibboleth. Because it is very important to reverse ventricular tachycardia, drugs are often used to slow AV nodal conduction.

It is, therefore, not a true classification in that it does not aggregate drugs into categories.

In Symposium on Cardiac Arrhythmias Eds. This site uses cookies. It starts by considering the range of pharmacological targets, and tracks these to their particular cellular electrophysiological effects.


Antidotes Contrast media Radiopharmaceuticals Dressings Senotherapeutics. Interactions Are unique to each individual drug but can include the potentiation of anticoagulent activity with warfarin coumadin.

Vaughan Williams Classification of Antidysrhythmic Drugs |

Journal of cardiovascular pharmacology and therapeutics. British Journal of Pharmacology. Prevent recurrence of paroxysmal supraventricular tachycardia Reduce ventricular rate in patients with atrial fibrillation. Calcium channel blockers and beta-blockers are useful for this indication. Class III agents predominantly block the potassium channelsthereby prolonging repolarization.

The result is an expanded but pragmatic classification that encompasses approved and potential anti-arrhythmic drugs.

Vaughan Williams Classification of Antidysrhythmic Drugs

Antidysrhythmiic are used to treat dysrhythmias, and some classes are also used in the treatment of angina and hypertension. Student of Nursing Blog An informative site of nursing information. Because sympathetic activity can precipitate arrhythmias, drugs that block beta 1 -adrenoceptors are used to inhibit sympathetic effects on the heart.

The main toxic effect of antidysrhythmic drugs involve the heart, circulation and CNS. Abnormal conduction is usually due to conduction block or a reentry phenomenon, with the latter being the most common cause of dysrhythmias. Antiarrhythmic agents Cardiac electrophysiology.